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Researchers have investigated and believe that Stem cells can help in developing individualised regenerative medicine. With the help of lots of proteins and RNA fragments, Organelles are made and it is vital for maintaining homeostasis, controlling ageing and development, and producing energy. The role of stem cells might be different organelles both across and within different cell types. The top researchers have looked at every type of stem cell with the help of an intracellular toolkit from the lab of Ahmet F. Coskun. He is a Bernie Marcus Early Career professor in the Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory University.

The goal to study this is to identify which cells are excellent to produce successful cell therapies. Ahmet F. Coskun said, “We are researching the positioning of organelles within cells and how they communicate.” Their recent research has recommended using an intracellular toolset. It will help to map the bio-geography of organelles in stem cells.

Nature portfolio journal is the first study that has been published in Scientific reports that looked at mesenchymal stem cells (MSCs). It has offered a promising treatment that will make sure to repair all defective cells. Also, it will modulate the immune response in patients. Coskun said, “Usually, the stem cells are used to repair defective cells or treat immune diseases, but our micro-study of these specific cells showed just how different they can be from one another. This proved that patient treatment population and customized isolation of the stem cells’ identities and their bioenergetics organelle function should be considered when selecting the tissue source. In other words, in treating a specific disease, it might be better to harvest the same type of cell from different locations depending on the patient’s needs.”

Coskun took the toolkit for further process and will now research about “spatial organization of multiple neighbouring RNA molecules in single cells.” He said, “The physical interactions between molecules create life; therefore, the physical locations and proximity of these molecules play important roles. We created an intracellular toolkit of subcellular gene neighbourhood networks in each cell’s different geographical parts to take a closer look at this.”

 

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