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    Get to Know All About Stem Cell Therapy for Retinitis Pigmentosa

    Millions of people worldwide are afflicted by Retinal Degenerative (RD) diseases that attack photoreceptors or neighboring Retinal Pigment Epithelium (RPE). In several different types, such as retinitis pigmentosa, age-related macular degeneration (AMD), adolescent macular degeneration (also known as Stargardt’s disease) and Leber’s congenital amau rosis, retinal degenerative (RD) were observed (LCA). Prematurity retinopathy, however is another leading cause of blindness in premature babies, not retinal degeneration.
    Special Access includes access to an advanced Retinitis Pigmentosa treatment regimen that uses larger stem cell concentrations, revolutionary growth factors for stem cells, comprehensive recovery, and numerous complementary treatments and supplements. This powerful integration of practical medicine with the most modern medical technology has helped patients make substantial changes.

    Symptoms of Retinitis Pigmentosa

    RP symptoms typically occur between the ages of 10 and 30, but during infancy, certain persons experience symptoms. Depending on what portion of the retina is affected, symptoms differ. RP is a progressive disorder, but for any person, the rate at which vision deteriorates varies. Many individuals with the condition eventually have a very small range of vision.

    In general, the rod cells of a human are first affected by RP. With peripheral (side) vision and seeing in low light or dark areas, rod cells help. “Night blindness,” which is impossible to see in low light, such as in a darkened space or outside at dusk, is also the first symptom. Naturally healthy eyes respond to dim light, but RP-affected eyes take even longer to do this or do not do at all.

    The glare from sunshine or artificial lights even disturbs certain individuals.

    Trouble with peripheral vision is also a typical early signs of RP. What you see on the edges, rather than directly ahead of you is peripheral vision.

    The central cone cells are damaged first in certain individuals, and the condition is called cone-rod dystrophy (CRD) rather than RP. Central cone cells assist with central vision, which is required to easily see other fine details for detailed activities such as reading, writing, driving, discriminating colors.

    Do you Know about Retinitis Pigmentosa?

    Retinitis pigmentosa (RP) is an eye genetic disorder which causes vision loss. Symptoms include night vision problems and reduced peripheral vision (side vision). When peripheral vision worsens, “tunnel vision” can be encountered by individuals. It is unlikely to have full blindness. The onset of symptoms is normally progressive and sometimes in infancy.

    Generally, Retinitis pigmentosa is inherited from the parents of a person. It includes mutations in one of more than 50 genes. The fundamental cause requires the gradual depletion in the back of the eye of rod photo receptor cells. In addition, this is accompanied by the depletion of photo receptor cone cells. Diagnosis is by an inspection that detects black pigment crystals in the eye.

    An electroretinogram, optical field testing, or genetic testing can be other supportive tests.
    At present, there is no treatment for retinitis pigmentosa. The use of low vision aids, adjustable lighting, or orientation and mobility therapy can be used in attempts to handle the condition.

    For gradual worsening, vitamin A palmitate supplements may be beneficial. In some persons with serious illnesses, visual prosthesis can be an alternative. It is estimated that it affects 1 in 4,000 persons.

    Global Stem Cell Care provides the best stem cell treatment for retintis pigmentosa in India, to the patients, who are suffering from this condition, and through the stem cell treatment, their symptoms have also improved. Only stem cell treatment is the cure for this condition as it helps to replace the damaged cells. Global Stem Cell Care has the best team that works for the effective treatment of this medical condition.

    Retintis Pigmentosa

    Get Stem Cell Therapy for Retinitis Pigmentosa in Delhi

    There is immense promise in the field of stem cell therapy for the treatment of Retinal Degenerative disease.
    Stem cells such as Umbilical Cord Blood-Derived Stem Cells (UCB-SC), Umbilical Cord Mesenchymal Stem Cells (Ucmsc) and Bone Marrow-Derived Mesenchymal Stem Cells (Bm-Msc) have the potential to regenerate and enhance vision from lost photo receptors and retinal neurons. Some studies indicate that stem cells. Through stem cell treatment, there is the regeneration of nerve tissues, blood supply improvements, and reduction in inflammation. Global Stem Cell Care offers the best stem cell treatment for Retinitis Pigmentosa in India that helps improve the condition.

    How Global Stem Cell Care Therapy Works ?

    In an ongoing Phase I/II clinical trial at the University of California, Irvine, an experimental stem cell-derived therapy intended to maintain and eventually restore vision in people with retinitis pigmentosa (RP) has shown a favorable safety profile.

    This safety update is positive news and a significant move in the right direction provided that this research is one of the first-ever stem-cell-derived therapies for RP.

    In the coming years, we at the Foundation look forward to further findings from this research as the trial progresses.
    The treatment requires the infusion of retinal progenitors into the vitreous, gel-like fluid in the center of the eye, the stem cells that are in the process of being retinal cells.

    . Researchers think that the cells will produce proteins that will maintain the current photoreceptors of the patient intact, avoid their degeneration and retain vision.

    Investigators also suspect that the proteins could rescue cones that have stopped light production, but have not fully degenerated.
    The photoreceptors that have the ability to read, identify faces and see under illuminated conditions are cones.

    What to Expect from Stem Cell Treatment for Retinitis Pigmentosa?

    • The stem cell therapy for Retinitis Pigmentosa requires the infusion of retinal progenitors into the vitreous, gel-like fluid in the center of the eye, the stem cells that are in the process of being retinal cells.

    • Researchers think that the cells will produce proteins that will maintain the current photoreceptors of the patient intact, avoid their degeneration and retain vision. Investigators also suspect that the proteins could rescue cones that have stopped light production, but have not fully degenerated.

    • Cones are the photoreceptors that are appointed the task to extend the ability to read, recognize faces, and see in lighted conditions. After the stem cell therapy for retintis pigmentosa by Global Stem Cell Care, the patient experiences better vision

    VIP Treatment to Patients at Global Stem Cell Care

    •  The retintis pigmentosa stem cell treatment sessions given to the patients at Global Stem Cell Care takes place in the VIP treatment room that is in the advanced clinic.
    • 24*7 supervision is maintained on the patients by the efficient medical team.
    • Global Stem Cell Care highly recommends the patients stay for a minimum of 3 days in Hospital.

    Global Stem Cell Care Treatment Procedure

    The treatments that take place in Global Stem Cell Care in Delhi, India usually last for about 3 days. The treatment protocol is safe and non-invasive. The patients can travel the next day. The following is the day-wise schedule for the patients.

    Day 1

    • Pick up from the Airport to the Hospital
    • Interaction between Dr and Patient, to clear all their doubts at that time
    • Admission procedure
    • Clinical examination & Lab test will be done prescribed by the doctor
    • Supportive Therapy

    Day 2

    • Global Stem Cell Care Procedure
    • Supportive therapies
    • Physiotherapy

     Day 3

    • Supportive Therapy
    • Physiotherapy
    • Discharging formalities
    • Drop back to the Airport

    Note

    • For Admission, carry the identity card (Passport/ Pan Card / Driving License)
    • Carry the hard copy of Patient reports

    Diagnosis of Retinitis Pigmentosa

    A series of tests are available to confirm a diagnosis of RP. These include:

    • Dilated Eye Check – You are given special eye drops to dilate your eyes during a dilated eye test, enabling the ophthalmologist to better see the retina at the back of your eye. Drops make you momentarily susceptible to light and make your eyes blur.

    • Retinal Photograph – You should use a special camera to take pictures of your retina, which helps to chart your RP progression. For a sensor called an OCT (optical coherence tomography) that uses dim red light, this can involve photographs of the retinal thickness.

    • Fluorescein Angiography – In order to gain more accurate photographs of the retina, a procedure called fluorescein angiography may also be recommended.
    • Visual Field Test – To assess if the peripheral vision has been impaired, a visual field examination is used.

    • Electro-diagnostic tests – To investigate how the retina functions, electro-diagnostic tests such as electroretinogram (ERG), electro-oculogram (EOG) and multifocal electroretinogram (mfERG) may be recommended.

    Under varying lighting conditions, the electrical activity of your retina is measured to assess which portion of your retina is not working normally. Most of these measures involve dilation of the eyes (as above) and also use a hard contact lens on each eye to assess the responses of the eye to various forms. Stem Cell therapy for Retinitis Pigmentosa in India by Global Stem Cell Care is the best-in-class.

    • • Visual acuity
    • • Experience of light
    • • Vision field
    • • View at night
    • • View in colour
    • • Nystagmus

    Possible Improvement

    Using umbilical cord derived adult stem cells, most patients with Retinal Dystrophies and associated retinal disorders whose Special Access has helped undergo groundbreaking therapies have demonstrated substantial changes, including enhanced visual acuity, improved visual field, improved light sensitivity and night vision.
    In comparison, the development of the condition following stem cell therapy has been considerably slower, resulting in years of retained vision.

    Retinitis Pigmentosa Stem cell-treated patients typically find changes in the following areas:
    Through stem cell treatment for glaucoma in India by Global Stem Cell Care, improvements can be seen in the symptoms of the patients. After the stem cell treatment, major improvements can be seen in the patients.

    • Intravenous administration
    • Liberation angioplasty
    • Intrathecal (lumber puncture)
    • Intraarterial
    • Subcutaneous
    • Surgical administration for stroke
    • Intramuscular

    Implantation

    1. Global Stem Cell Care has the best stem cell therapy for Retinitis Pigmentosa in India. The implantation stage is very important and an ideal pick during the treatment.
    2. The stem cells that are used in the implantation stage are the autologous mesenchymal foundational microorganisms from bone marrow.
    3. From a large portion of the bone marrow, undeveloped cells are isolated by an uncommon machine and infused by intra-thecal infusion; the staying bone marrow is sent to a research center for intensification of cells and giving cytoplasmic markers for making neuro ancestor cells. These ancestor cells are infused by intravenous dribble.
    The following is the structure that is followed during the implantation stage:

    Mechanism

    The following is the potential mode of action for restoring retinal cells. Stem cells secrete neurotrophic factors, such as BDNF, GDNF, which can facilitate neural and retinal ganglion cell differentiation of grafted cells, prevent apoptosis, enhance angiogenesis, reduce inflammatory stimuli, and promote survival of grafted cells.
    Stem cells facilitate the division of cells and have an early response to damage, ischemia and degeneration. Mesenchymal stem cells also have paracrine effects that improve angiogenesis, decrease inflammation, have anti-apoptotic and chemotactic signalling effects, encourage beneficial extracellular matrix remodelling, promote the activation of resident adjacent stem cells, and restore the retinal pigment epithelium
    .

    Frequently Asked Questions

    Retinitis Pigmentosa is a genetic condition that results in a progressive deterioration of sight, allowing night vision and peripheral vision to deteriorate. Owing to progressive disruption to the retina-photosensitive cells-of the skin, retinitis Pigmentosa occurs. It starts with damage to the cells of the rod, cells responsible for vision in darkness, and then damage to cone cells, cells responsible for color vision and acuity.

    Retinitis Pigmentosa is attributed to a genetic disorder and is a hereditary condition that arises in one or more than 50 genes due to gene mutation. However while external factors can decide and influence the rate of disease progression, they do NOT cause it. According to study, numerous types of gene mutations cause the photoreceptor cells of the eye to fail, which in turn contributes to the gradual degradation of the retinal cells.

    Yes, it is possible to spread Retinitis Pigmentosa from parents to their offspring. If either parent has a dominant gene for this disorder, they have a 1 in 2 chance of passing it on to their infant, while if the recessive gene for RP is borne by both parents, they have a 1 in 4 chance of passing it on to their offspring.

    In an infant as young as 10 years of age, the symptoms of Retinitis Pigmentosa may be established, and while the pattern and gradual severity of this condition vary between persons, it normally presents in the form of the following symptoms:

    1: Decreased visibility at night
    2: Vision blurred and smudged
    3: Unclear Differentiating Colour
    4: View of the Tunnel
    5: Photophobia (greater visual aversion and discomfort/pain endured when exposed to bright lights)

    Vision is affected by Retinitis Pigmentosa in three major ways:
    1: Causes blindness at night.
    2: Tunnel vision triggers
    3: Ambiguous distinction between color and acuity

    No, RP rarely causes complete vision loss, but even after a gradual worsening of the condition over a prolonged period of time, the majority of individuals suffering from it maintain a portion of their central vision.

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