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TYPES OF MESENCHYMAL STEM CELLS (MSCS) AND THEIR PRIMARY MECHANISMS OF ACTION
Mesenchymal stem cells are one of the most researched kind of cells for stem cell-based therapies. The diversified capabilities can lead to promising outcomes in different conditions. This guide will discover some common types of MSCs and how they work. Let’s start the post by knowing what actually are MSCs.
What are Mesenchymal Stem Cells?
Mesenchymal stem cells are multipotent stem cells that are found in the bone marrow, which are crucial for making and repairing skeletal tissues. In addition, these cells are used in treating various diseases due to their self-renewable and differentiated properties.
MSCs can be collected from different tissue such as adipose tissues, bone marrow, blood, liver, and umbilical cord tissue. MSCs are used in the treatment of other diseases because of their differentiation, immunomodulatory, self-renewable, and anti-inflammatory properties. Studies like in-vivo and in-vitro have supported the mechanisms, efficacy, and safety of mesenchymal stem cell therapy in medical applications.
According to a study conducted by Girolmina Crigna. Through endocrine and paracrine modes of action, MSCs exert their regenerative results, which comprise various influences like mitogenic, anti-apoptotic, anti-oxidative stress, and angiogenic.
In the next section of this post, we’ll learn about How Mesenchymal Stem Cells work in the body.
The working mechanism of MSCs
Mesenchymal stem cells utilize their self-sustaining, signalling, and differentiation characteristics to impact positive and reasonable changes in the body. These cells can also regenerate by developing and dividing into multiple cell types that are present in a specific organ or tissue.
Now let’s look closely at some properties of the MSCs in brief.
- Immunomodulatory property-
MSCs can modulate the immune system by facilitating an inflammatory response when the immune system is under-activated and compressing it when the system is over-activated. These cells can be crucial in preventing the immune system from attacking itself, to what one may see in many autoimmune disorders.
- Exosome signalling
The characteristics of MSCs not only have the potential to differentiate or have the ability to replace the damaged cells or tissues but are also mediated by their secretome through a paracrine mode of action.
- Homing properties
MSCs can able to target particular areas of concern due to their inherent ensconcing capabilities. If MSCs administered systemically can be defined as stimulating circulation and migrating to the injury part.
- Differentiation character
These cells can re-birth and differentiate into different cell types. According to the study conducted by Almalki- “The differentiation of MSCs into specific mature cell types is controlled by various cytokines, growth factors, extracellular matrix molecules, and transcription factors.”
Many studies were conducted and have outlined the varied abilities, as mentioned before, and these attributes enable MSCs to use in various clinical procedures for multiple degenerative conditions.
The effectiveness of MSCs is still being studied, and several patients experience benefits such as reduced pain, long-term relief from symptoms, and improved quality of life. If someone you love is facing degenerative medical conditions MSCs may be the right option to explore further. If you would like to discover more about the MSCs and their uses contact us today!