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    Get to Know All About Stem Cell Therapy for Osteoporosis

    Osteoporosis is a bone condition caused by the body losing too much bone, not making enough bone, or both. As a result, bones become brittle and can snap as a result of a fall, sneezing, or small bumps. The term “osteoporosis” refers to a porous bone. Healthy bone resembles a honeycomb as seen under a microscope. The cracks and spaces in the honeycomb are much larger in osteoporosis than in healthy tissue. Osteoporotic bones have decreased density or bulk, and their tissue composition is irregular. Bones degrade and are more likely to crack as they become less dense. If you’re 50 or older and you’ve fractured a bone, talk to the doctor about getting a bone density test.

    Symptoms of Osteoporosis

    Osteoporosis does not have any symptoms or warning signs in the early stages. Many patients with osteoporosis are unaware of their disease until they suffer a fracture. If signs do occur, the following are some of the most common ones:
    Grip power is weakened, and nails are thin and fragile. If you don’t have any symptoms but have a family history of osteoporosis, you can see your doctor to determine your chance. Osteoporosis is a disease that affects the bones. Osteoporosis will escalate if not treated properly. Fractures become more likely as bones become smaller and weaker.
    An injury from a fall or even a strong sneeze or cough may be signs of serious osteoporosis. Back or neck pain, as well as a lack of height, are examples. A compression fracture can result in back or neck pain as well as a loss of height. This is a crack in one of the neck or back vertebrae that is so frail that it fails under normal spinal pressure. If you have an osteoporosis-related injury, the length of time it takes to recover is determined by a variety of factors. Many factors include the location of the fracture, the severity of the fracture, as well as the age and medical background.

    Do you know about Osteoporosis?

    An osteoporosis-related fracture has a greater risk of occurring in women than a heart attack, stroke, or breast cancer combined. Owing to this disease, half of women, double the incidence of men, can expect to break a bone at any stage in their lives. Eighty percent of the ten million Americans diagnosed with osteoporosis currently are women.

    Men account for 20% of osteoporosis sufferers. Since osteoporosis is commonly thought of as a female illness, men may overlook their own risk. However, osteoporosis affects about 2 million men in the United States. Men over 50 are 27 more more likely to break a bone due to osteoporosis than they are to have prostate cancer (11.3 percent ).

    Men are half as likely as women to be tested or treated for osteoporosis, despite the fact that 25% of men will suffer osteoporosis-related bone fractures at any stage in their life. Men are more likely than women to die from a fracture caused by osteoporosis.

    This is particularly true in the case of hip fractures. Men account for one-third of all hip fractures worldwide, with up to 37% dying in the first year following the fracture—twice the incidence faced by women.

    While results indicate that men are more likely to have additional medical issues at the time of the fracture and are more vulnerable to complications after surgery, researchers aren’t sure why men have a higher mortality rate.

    Osteoporosis

    Get Stem Cell Therapy for Osteoporosis

    In several areas of medicine, particularly musculoskeletal diseases including osteoporosis, the use of stem cells for tissue regeneration has sparked great optimism. Stem cell therapy for osteoporosis can help to replace lost mineral density by raising the number of resident stem cells or restoring the role of resident stem cells that can proliferate and differentiate into bone-forming cells, reducing fracture susceptibility.
    The regeneration of new bone and connective tissue is aided by stem cell therapy. Stem cells are used in this regenerative process to regenerate and repair bones, reducing the chance of bone loss. Stem cell treatment may be able to help people with osteoporosis reverse their symptoms. Bones are often thought of as static, stable, and structural, but they are really a highly complex and active
    organ. Old bone is constantly replaced by fresh bone using endogenous stem cells. Stem cell treatment helps to improve this regular repair process. Stem cells develop cartilage before becoming new tissue. Intravenous administration of stem cells derived from bone marrow, adipose tissue, or umbilical cord blood tissue may be used to treat osteoporosis. Treatments of drugs or small molecules that attract endogenous stem cells to osteoporotic sites may also be used.
    The interior structure of the bone deteriorates with age, leaving the bone less dense, smaller, and with a lack of function. Studies show a connection between osteoporosis and a lack of or deficient stem cells. Global Stem Cell Care in India offers the best and the most reliable treatment to the patients looking for osteoporosis treatment.

    How Global Stem Cell Care Therapy Works ?

    The use of stem cells has been shown to improve bone resilience,

    This discovery will change how doctors treat osteoporosis, and shape.

    plasticity, and it could mean the conventional osteoporosis therapies (antiresorptive and anabolic drugs)

    will be phased out due to their many side effects.

    Global Stem Cell Care extends the best and the most experienced staff when it comes to stem cell treatment for osteoporosis and other ailments.

    What to Expect from Stem Cell Treatment for Osteoporosis?

    • Osteoporosis is a crippling condition that impacts millions of people around the world. The majority of current osteoporosis therapies are bone-resorbing medications with a variety of side effects.

    • The use of stem cells for tissue regeneration has sparked a lot of excitement in the medical community, including in the field of musculoskeletal disorders.

    • Through either growing the amount or restoring the activity of resident stem cells that can proliferate and differentiate into bone-forming cells, stem cell therapy for osteoporosis could theoretically decrease fracture susceptibility and augment reduced mineral density.

    • Exogenous induction of mesenchymal stem cells (MSCs), which are usually obtained from bone marrow, adipose, and umbilical cord blood tissues, or procedures of drugs or small molecules that attract endogenous stem cells to osteoporotic sites, are two options for treating osteoporosis. The confusion of stem cell fate and biodistribution after cell transplantation is the key barrier to cell-based osteoporosis treatment.

    VIP Treatment to Patients at Global Stem Cell Care

    • The therapy sessions given to the patients at Global Stem Cell Care in India occur in the VIP treatment room in the advanced clinic.
    • 24*7 supervision is maintained on the patients by the efficient medical team.
    • Global Stem Cell Care highly recommends the patients stay for a minimum of 3 days in Hospital.

    Global Stem Cell Care Treatment Procedure

    Day 1

    • Pick up from the Airport to the Hospital
    • Interaction between Dr and Patient, to clear all their doubts at that time
    • Admission procedure
    • Clinical examination & Lab test will be done prescribed by the doctor
    • Supportive Therapy

    Day 2

    • Stem cell Procedure
    • Supportive therapies
    • Physiotherapy

    Day 3

    • Supportive Therapy
    • Physiotherapy
    • Discharging formalities
    • Drop back to the Airport

    NOTE

    • For Admission, carry the identity card (Passport/ Pan Card / Driving License)
    • Carry the hard copy of Patient reports

    Diagnosis of Osteoporosis

    Your doctor will review your medical records and do a physical test to see whether you have osteoporosis. They can also do blood and urine samples to look for problems that may cause bone damage. If your doctor suspects you have osteoporosis or are at risk of having it, a bone density test would most likely be recommended. Bone densitometry, or dual-energy X-ray absorptiometry, is the name of the test (DEXA). It uses X-rays to determine the density of the wrists, hips, and spinal bones. These are the three places where osteoporosis is most likely to occur. This non-invasive test will take anywhere from 10 to 30 minutes to complete.

    • Global Stem Cell Care in India

    Possible Improvement

    A primary aim of modern therapy is to combatant medications is to decrease the resorption of bone, but the seriousness of their side effects is a major concern. as in the future, along with other cell-based therapeutic options such as mesenchymal stem cells (MSCs) could be used in the treatment of osteoporosis.

    • Intravenous administration
    • Liberation angioplasty
    • Intrathecal (lumber puncture)
    • Intraarterial
    • Subcutaneous
    • Surgical administration for stroke
    • Intramuscular

    Implantation

    The following is the structure that is followed during the implantation stage:

    Mechanism

    As a result of the pathogenesis of primary osteoporosis, the rate of bone formation exceeds that of bone dissolution, resulting in increased bone turnover. Primary osteoporosis has several pathogeneses, including homing disorders, impaired osteogenic differentiation, and MSC senescence. The occurrence and progression of osteoporosis are also influenced by an unbalanced microenvironment and disordered immunoregulation.
    MSCs migrate to bone marrow to perform a local functional and restorative role, which is the first step in bone repair. MSCs are thought to follow a similar path to leukocyte homing. The first step involves the cells tethering and rolling with the endothelium, causing the cells to decelerate in the bloodstream. The activation of cells by G protein coupled receptors is the second step, followed by integrinmediated, activation dependent arrest in the third step. The cells then migrate through endothelial cells and the underlying basement membrane in the final step.

    When homing ability is impaired, it is difficult to ensure that enough MSCs reach the damaged tissue, obstructing bone repair. More importantly, their research highlighted the beneficial effects of overexpression of CXC motif receptor 4 (CXCR4) on MSC migration. MSCs from patients with osteoporosis showed a significant increase in migration and invasion in response to BMP2 or BMP7 stimulation. Nonetheless, when compared to healthy controls, the invasion and migration capacity decreased significantly. To solve this problem, increasing the total number of MSCs through cell transplantation or improving MSC homing through gene modification or targeted peptides would be beneficial.
    Multiple transcription factors and signalling pathways control the differentiation of common mesenchymal progenitor cells into various types of skeleton-related cells. The determination of an MSC to become an osteoprogenitor, in which runtrelated transcription factor 2 (RUNX2) directs mesenchymal progenitor cells to preosteoblasts while inhibiting chondrocyte and adipocyte differentiation, is the first step in osteoblastic differentiation. Following that, RUNX2 and Osterix (OSX) direct preosteoblasts to immature osteoblasts that express bone matrix protein genes, effectively removing the possibility of chondrocytic differentiation. Furthermore, it is widely acknowledged that the BMP signalling pathway is important in regulating MSC adipogenic and osteogenic differentiation. The osteogenic differentiation of stem cells is accelerated by BMP2. When combined with activators of the peroxisome proliferator activated receptor (PPAR), BMP2 can be a potent adipogenic agent.Osteoporosis is characterised by a decrease in osteogenic differentiation. MSCs from osteoporosis patients produced a type I collagen-deficient extracellular matrix that favoured adipogenic differentiation in the preliminary stage. Wang et al30 compared the MSCs of postmenopausal women with osteoporosis to those of healthy volunteers, finding that the sensitivity of MSCs to osteogenic differentiation was reduced in osteoporosis patients. MSCs with better osteogenic differentiation ability should be transplanted to reverse this trend. It is also possible to reactivate MSCs’ osteogenic differentiation ability using gene modification and an in vitro activator.

    Frequently Asked Questions

    A. Many risk factors are within your influence if you make healthy lifestyle decisions. There are the following:
    – Have enough vitamin D and calcium
    – Exercise daily
    – Quit smoking
    – Avoid substance misuse
    – Work with the doctor to correct hormone imbalances
    – More about the long-term effects and side effects of the drugs you’re taking.

    A. The first is that women’s bones are narrower and lighter than men’s. The second has to do with hormones: When a woman reaches menopause, her hormone levels plummet dramatically. This loss delays bone remodelling and can cause the body to lose bone mass more quickly. During menopause, this persists for many years. The rate of bone deterioration gradually returns to premenopausal levels, although in the interim, postmenopausal women are more likely to suffer a fracture. The good thing is that osteoporosis is not a natural feature of the ageing process. There are a variety of lifestyle choices that will help you protect your bones and reduce your risk of developing osteoporosis. You can bring up your bone wellbeing with your healthcare professional if you haven’t already.

    A. If you need to take them for other reasons, certain drugs will damage your bones. Often discuss the complications and side effects of your medications with your healthcare provider, as well as how they can affect your bones.

    A. A fall can cause injury to someone of any age. Because of the increased risk of fracture in people with osteoporosis, it is important that they prevent trips and falls. Here are a few pointers to help you from falling:

    • Canes can assist with osteoporosis
    • If you use one, use a cane or walker
    • Use rubber-soled shoes to avoid slipping
    • When the roads are slippery, step on the lawn
    • Use ice on snowy sidewalks
    • Keep rooms free of clutter
    • Wear low-heeled shoes
    • Avoid walking in socks or stockings
    • Make sure rugs have skid-resistant backs
    • Ensure that both stairwells and walkways are well lit
    • Handrails can be installed on both sides of the steps
    • Install grab bars by the tub, shower, and toilet in the bathroom – Invest in a non-slip bath mat
    • Keep a torch by your bedside
    • Increase the number of lights in your house such that all rooms are well-lit – Using a durable step stool with a handrail and wide steps to access high cabinets.

    A. The National Osteoporosis Foundation estimates that 54 million Americans suffer from osteoporosis or osteopenia. According to studies, one out of every two women and one out of every four men over the age of 50 would break a bone due to osteoporosis.

    A. Well, indeed! And if you have osteoporosis, you will participate in most activities. According to research, some exercises are more effective than others at reducing bone loss: jogging, biking, basketball, and weight lifting. Owing to the lack of “loading” the bones through interaction with the ground, some sports have several benefits but have little to no impact on bone density: Cycling, diving, and yoga are also good options.

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