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    Get to Know All About Stem Cell Therapy for Critical Limb Ischemia

    By definition, Critical Limb Ischemia means inadequate blood provision. As used for limbs, the disease is so extreme that it exposes the legs to an amputation risk. Blocking blood to the low ends is too important to leave the limb dead because of a loss of flow. There are many medical conditions, including infection, artery disease, or hardships in the arteries that contribute to vital limb ishemia (CLI). Diabetes is also a common risk factor for CLI because it affects the circulation and cure directly. Any CLI care, like stem cell therapy, is aimed at enhancing the quality of life of the patient.

    Critical Limb Ischemia can be treated by stem cell therapy because of its regenerative potential. This disease often results in amputation due to inadequate blood supply to extremities. In India’s expanding medical landscape, stem cells’ regenerative capabilities are under study at Global Stem cell Care. Mesenchymal stem cells (MSCs) from adipose tissue or bone marrow are applied to invigorate angiogenesis—promoting new blood vessel build-out, anticipation of limb salvage, alleviation of disease burden, and improved mobility, ultimately bypassing invasive manoeuvres.

    Do you Know About Critical Limb Ischemia ?

    What are the risk factors associated with Critical Limb Ischemia for CLI patients:
    The risk of diabetes rises up to three times the risk of having CLI. Diabetic patients are also more likely to become sick with foot ulcers. They normally feel decreased discomfort because of peripheral neuropathy and have unsanitary sores or ulcers. This raises the risk of leg amputation.

    The peripheral artery disease leads 75% to smoke of the tobacco. The smoke of tobacco contains nicotine and carbon monoxide that can lead to artery development. Studies have shown the risk of coronary disorders being reduced from reduction of smoking.

    Excessive pressures of the blood vessels may lead to a slowing of the arteries due to hypertension or high blood pressure. Stroke and coronary diseases have been involved. One path to treatment has been CLI control of hypertension medications.

    Dyslipidemia is an elevated blood lipid profile element that requires elevated overall amounts of cholesterol, high triglyceride levels and lower-density lipoprotein (LDL), and low lipoprotein levels (HDL). It is related to obesity and can probably be regulated by diet.

    Obesity may help develop chronic limb ischemia directly or indirectly. It is associated with elevated cholesterol and hypertension. Investigations have found that obese people will occlude their arteries by inflammatory reactions in their corps. The problems of CLI are compounded and the healing process of corpses can be slowed down.

    The adjustment to the lifestyle will also certainly be a realistic solution to lowering the likelihood of developing CLI by not smoking, weight loss, and dietary regulation. However, it is beyond our reach to avoid the occurrence of a disease in such advanced or untreatable situations. The stem cell treatment for Critical Limb Ischemia is offered by the best multi-specialty hospitals in India. Stem cells help return blood in ischemic patients to blood flow to avoid amputation.

    Symptoms of Critical Limb Ischemia

    Critical Limb Ischemia is an advanced stage of a fatty deposits or plaques in the peripheral artery disease caused by an increase in cholesterol. This plaque triggers the blood supply restriction in the arteries. Oxygen delivery is disrupted in the absence of blood oxygen and tissue death or necrosis eventually occurs. While age is a key influence for Critical Limb Ischemia symptoms, CLI is similarly responsible for lifestyle associated disorders, such as obesity, high blood pressure, or high cholesterol. Diabetic or familial atherosclerosis patients are often susceptible.


    • Sudden severe "rest pain" in patients with Critical Limb Ischemia occurs, particularly at night. Resting pain in the legs is a burning pain in a reclining or high position of the leg.
    • It is when the arteries do not circulate in the blood which is healed by sitting or standing. The legs and absence of pulse can result in sorrow and engulf. Patients also develop non-healing skin ulcers, which may be progressed.


    Patients with other persistent leg pain, such as peripheral neuropathy, can find it difficult to distinguish the presence of rest pain. Often a discretionary evaluation would be the marking of a wound as non-healing. However, a variety of physical results and quantitative hemodynamic criteria can be used to help a diagnosis of ischemia of chronic critical limb. Typical physical signs are missing or reduced pedal pulses, soft, faint skin of the feet and thighs, and the lack of calves’ muscles.

    A hand-held Doppler probe and blood pressure cuff can easily be done with quantitative measurements of blood flow. The manguet is elevated before the pulse distal from the manguette is stopped hearing Doppler. The mango is steadily swollen until the signal is found again. The systemic pressure reported is this calculation. The ankle-brachial index is another commonly used metric.

    Doppler probes are employed by vascular laboratories to gauge the pulse volume waveform at specific points in the leg arteries. By observing a change in the Doppler waveform from triphasic to biphasic to monophasic and then to stenotic waveforms, it is possible to determine sites of arterial obstruction.

    Differential Diagnosis

    Ischemic rest pressure may be mistaken for night cramps, arthritis, or diabetic neurotherapy. In calf muscles, night cramps are triggered and the patient is normally shaken out of sleep by muscle massage, by pacing or using antispasmodium. Metatarsal bone arthritis patients may have foot pain. This discomfort mostly happens at night and can be alleviated by standing. The distinctive aspect of arthritic pain is that it typically appears in irregular or erratic intervals, while ischemical rest pain often happens after a certain recumbency interval.

    The pain in the foot may also occur and is occasionally associated with reduced pulses and trophic skin changes. Diabetic neuropathy However, this discomfort is not reliably related to relief. Differentiating characteristics may also be the features that have been reported with diabetic neuropathy including light loss (i.e. a monofilament test) and lower vibratory meaning.

    Conservative Treatment

    Shift to the risk factor including cessation of smoking, regulation of blood pressure, good glycemic control and lipid reduction should be developed. The risk of myocardial infarction, stroke, or death in peripheral vascular patients have been dramatically decreased by aspirin antiplatelet treatment and arterial reocclusion occurrence is also decreased after angioplasty or bypass grafting.

    It is important to offer pain relief to patients with ischemic rest pain to address the underlying structural cause of poor blood flow, such as heart failure. Where pain persists after four to eight weeks of pain medicated conservative therapy and pain-optimal interventions, the possibility of surgical action, including risk and benefit of the procedure should be explained to the patient.

    Revascularization and amputation requires surgical intervention. If the patient is re-vascular and an acceptable operating candidate, arteriography is also done for further assessment and preparation. Some centers use magnetic resonance angiography to mitigate their chance of color sensitivity as a substitute or an extension to arteriography.

    Wounds that are non-healing

    The presence of an infection should be measured in patients with non-healing wounds or gangrene. Antibiotic treatment, operative debridements or both are required for contaminated wounds. Conservative treatment involves advising people how to prevent wound damage, including the use of appropriately flexible shoes. The patient can be seen weekly before the wound cure Dressings can be changed constantly.

    Critical limb ischemia (CLI) is a severe condition characterised by insufficient blood flow to the limbs, particularly the legs, resulting in tissue damage and potential limb loss. CLI typically progresses through four stages:

    In the early stages, blood flow to the limbs is compromised, but symptoms may not be apparent. However, underlying vascular issues such as peripheral artery disease (PAD) are present, increasing the risk of developing CLI.

    As the condition worsens, patients may experience intermittent claudication, which manifests as pain, cramping, or weakness in the affected limb during physical activity. These symptoms typically improve with rest.

    In this stage, patients experience persistent pain in the affected limb, even at rest. This pain is often severe and may disrupt sleep, affecting the patient’s quality of life.

    Without adequate blood flow, tissues in the affected limb become deprived of oxygen and nutrients, leading to tissue damage, ulcers, or gangrene. This stage represents a critical juncture where prompt intervention is necessary to prevent irreversible damage or limb loss.

    Since critical limb ischemia is a severe form of PAD (peripheral artery disease), the primary risk factor for developing critical limb ischemia is untreated atherosclerosis. As atherosclerosis is the primary cause of PAD, the risk factors for PAD and CLI are similar, including:

    • Age
    • Smoking
    • Obesity
    • Diabetes
    • Inactive lifestyle
    • High cholesterol
    • High blood pressure
    • Family history
    Physical Therapy
    Physical Therapy
    The least invasive and most appropriate treatment for PAD conducted by Physiotherapists would be by prescribing an exercise program. Exercise therapy involves walking until reaching pain tolerance, stopping for a brief rest, and walking again as soon as the pain resolves. These walking sessions should last 30 to 45 minutes, 3 to 4 times per week, for at least 12 weeks.
    Rehabilitation Therapy
    Rehabilitation Therapy
    Patients with CLI typically require interventions to reestablish blood supply to their limbs. There is currently minimal understanding of the role of exercise rehabilitation after revascularization procedures in this vulnerable population. This is the first clinical to understand the role of exercise for these patients. We hypothesize that exercise rehabilitation after revascularization will improve these patients' quality of life and functional capacity.
    It is a technique in which practitioners stimulate specific points on the body – most often by inserting thin needles through the skin. Blood flow and oxygenation were increased in peripheral areas in the control group. In the PAD patients, blood flow was significantly increased in the dorsum of the foot and ankle after the first and at all 4 points after the final treatment, whereas cutaneous oxygenation was not significantly increased.
    • Intravenous administration
    • Liberation angioplasty
    • Intrathecal (lumber puncture)
    • Intraarterial
    • Subcutaneous
    • Surgical administration for stroke
    • Intramuscular


    The following is the structure that is followed during the implantation stage:



    The blood is first extracted and then a minimally invasive bone marrow harvest is carried out via the crest of the iliac. Around 100ccs of the bone marrow of a patient are collected using a minimally invasive, aspiration procedure for the bone marrow. TruStem Cell therapy employs an effective system of entering the bone marrow in tandem with local anesthetics, which makes for reliably bigger cell collections, incredibly low levels of pain/invasiveness in most patients and higher sterility levels.


    Bone marrow aspirates are used preferentially because they are one of the richest suppliers of the human body’s most economical stem cells and come under the FDA minimum modification guidelines.

    Process & Activation

    Our devoted laboratory with our team of technicians, is quickly shipped both the blood and the bone marrow. Once the sample has been in the laboratory, our patented proprietary procedure insulates and excites regenerative cells and concentrates healing factors at hyper-physiological speeds to make a highly efficient, injectable cure more conveniently possible.


    Stem Cell Therapy utilizes both systematic and novel administration methods to fully saturate the body with stem cells while targeting specific areas of injury. Stem cell treatment for Critical Limb Ischemia is offered by the best stem cell multispecialty hospitals.

    Critical Limb Ischemia

    Get Stem Cell Therapy for Critical Limb Ischemia

    CLI stem cell therapy is a cutting edge technique that uses the stem cells of the patient to improve life quality and reduce signs of illness. This CLI treatment is offered in two forms to patients:

    • A systemic IV injection, which is sent to the whole body of stem cells
    • Based injection located in the affected limb

    Stem cells are cells which have not yet made up their minds. They are able to become any cell such as nerves, sternum, cartilage, muscle or tendon in this undifferentiated condition. As a part of the stem Cell Therapy, critical limb ischemia is adipose, the fat tissue stem cells are available and they have a greater immunomodulatory potential, making them safe to use as well. They are readily available.

    The stem cells are safely extracted from the body of the patient and redistributed to the appropriate region by stem Cell Therapy. This will be the lower limbs of vital limb ischemia therapy.

    How Global Stem Cell Care Therapy Works ?

    The treatment of stem cells requires the administration of tissue injury to stem cells. The intrinsic capacity for the creation of new vessels and arteries in these stem cells is the neo-vascular phase, which replaces the weakened arteries. It provides tissue regeneration and constant blood flow and delivery of oxygen.

    The stem cell treatment clinical process includes three main steps:

    Extracting between 150-250 ccs of fat tissue – no diseased or refuse risk since it is taken straight from the patient. The harvest is minimally invasive, and the tissue is similarly liposuctive removed from the abdomen.

    Fat tissue recycling — After the tissue is removed, it goes to the on-site processing laboratory. At this point, the purpose is to isolate and activate the stem cells using a cell therapy-specific procedure.

    Treatment administration — Patients are returned with harvested and activated stem cells.

    All three phases – harvesting, sorting and management – function together to help CLI patients alleviate symptoms such as:

    Skin cold

    Recurrent accidents

    Muscle pain Muscle pain

    Stem cell therapy uses the cures in the body to safely and effectively develop. Since there’s no fixed timetable for stem cell therapy improvements, it could take a few weeks or months to see notable results. Ischemia of the legs happens in two ways:

    (1) The lower legs or feet can be constantly burning, which gets worse after the limb has been lifted, or

    (2) ulcers and tissue loss. If some concern is present, seek immediate care. Global Stem Cell Care in India extends the best treatment for stem cells and the procedure is highly reliable and is done under supervision of experts.

    VIP Treatment to Patients at Global Stem Cell Care

    • The therapy sessions given to the patients at Global Stem Cell Care occur in the VIP treatment room in the advanced clinic.
    • 24*7 supervision is maintained on the patients by the efficient medical team.
    • Global Stem Cell Care highly recommends the patients stay for a minimum of 3 days in Hospital.

    Our Promise

    What to Expect from Stem Cell Treatment for Critical Limb Ischemia?

    • Stem cell treatment helps to reduce disease-related signs and risks, such as tissue death, by treating the vital limb ischemia. In certain cases, our patients with critical limb ischemia see improvements:

    • Improved blood supply to the limbs

      Pain drop

    • Fewer sores and skin ulcers

      Less tiredness.

    • Obviously, medical care is without promises, but stem cell treatment is a promising alternative to many conventional options. Although the FDA has not been approved for critical limb ischemia therapy, trials have demonstrated that it is worth considering a safe and successful CLI treatment.

    • In order to provide each patient with reasonable perceptions of this treatment, we provide an experienced advocate. Stem Cell treatment in Delhi is offered by the best multi-specialty hospital in India.

    • Changes in social interaction
    • Enhanced verbal and nonverbal communication
    • Increased language learning ability
    • Reducing repetitive behavior
    • Improved mental development
    • Better Muscle tone

    Possible Improvements

    There are therapies that can help improve the quality of life of a patient can be increased by minimizing symptoms and complications associated with diseases. Improvements of one or more disease-related complications, such as: decreased blood supply to the extremities, inflammation, skin ulcers, sores, weakness, etc. can also be found in critical limit Ischemia patients.

    Frequently Asked Questions

    Stem cells are like building blocks, and may shape new, stable tissues to replace diseased or wounded cells, like new knee cartilage, or to help speed recovery in different parts of the body. Adult stem cells are normally present but not activated. Adult stem cells, known as progenitor cells, stay asleep until necessary. It is currently not clear whether or not cells are transforming into the appropriate type of cell or only beginning and encouraging healing, but we know that they have reparative capacities to facilitate cell healing.

    A plentiful supply of up to 10 times more stem cells or adipose derived stem cells than bone marrow

    Greater than adult stem cells proliferation

    They are rapidly regenerating

    They are young and adaptable

    The ageing process has not affected them

    Environmental contaminants are not impaired

    The purpose of stem cell therapy is to use a patient’s own sustainable supply of substitute cells for the treatment of common as well as life-threatening conditions, without the need of organ transplants or other surgery.

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