As of 2021, around 184 million individuals have been infected with the coronavirus illness, which is caused by the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2). (3) Since the beginning of the epidemic, (SARS-CoV-2) more popularly known as COVID-19 has caused more than 4.7 million deaths globally, and the numbers are continually rising. In spite of the virological features and pathogenesis (the process by which a disease or condition is formed), there is presently no particular treatment strategy for this illness. As a result, the body’s immune system may be weakened or even destroyed in severe COVID-19 infections.
For the treatment of influenza in animal models, mesenchymal stem cell therapy has shown to be a significantly safer alternative to standard therapies than the latter.
The current advancement in mesenchymal stem cell treatment for COVID-19 has been detailed in a study published in “Signal Transduction and Targeted Therapy” by Lei Shi et al., and the implications and problems of the field have been emphasised.
Efforts in clinical trials have been successful.
The research by Lei Shi et al. analysed six clinical studies assessing the efficacy of MSCs for moderate or severe COVID-19, as well as three trials for patients with acute respiratory distress syndrome (ARCS). It has been concluded that mesenchymal stem cell treatment (MSCT) is safe and well-tolerated.
MSCs were obtained from umbilical cord, adipose tissue, or bone marrow-derived mononuclear cells and administered intravenously in these experiments.
A considerable decrease in COVID-related symptoms was seen in the study participants, as well as an improvement in other clinical indices and an increase in FiO2 and PO2 levels. In a number of investigations, inflammatory cytokine levels were shown to decrease. The volume of pulmonary fibrosis lesions was also reduced in one study. According to the data collected from the research participants, mesenchymal stem cell treatment seems to be both safe and effective for COVID-19 patients. (1)
An explanation of the post-acute COVID-19 condition. Covid-19 (Long haul)
There are more and more reports of long-lasting consequences after an acute COVID-19 infection, similar to the post-acute viral syndromes that have been seen in survivors of earlier highly pathogenic coronavirus outbreaks. Post-acute COVID-19, a condition defined by persistent symptoms and/or delayed or long-term problems beyond 4 weeks after the beginning of symptoms, has been recognised thanks to patient advocacy organisations that have contributed to its identification.
Patients’ testimonies reveal that whereas 65 percent of those treated for a severe type of COVID-19 healed totally upon discharge, 35 percent remained unwell more than two weeks after being hospitalised.
Signs and symptoms of long-term COVID exposure
COVID-19-positive individuals may have the following long-term symptoms.
Long-term signs and symptoms of COVID include:
Shortness of breath and tightness in the chest; memory and concentration issues (“brain fog”); trouble sleeping (“insomnia”); heart palpitations; dizziness; pins and needles; joint pain; melancholy and worry.””
tinnitus, ear pain, nausea, vomiting, diarrhoea, headaches, sore throat, changes in taste or smell, and rashes are just a few of the symptoms you may experience.
Long-term COVID stem cell treatment
Post-acute COVID-19 symptoms may be alleviated by using MSCs (Mesenchymal Stem Cells) produced from cord tissue. These cells reduce inflammatory cytokines, modulate the immune system, and speed up recovery time.
Goals of treatment
More and more clinical studies involving Mesenchymal Stem Cells have been done during the last several years as a possible treatment for a wide range of illnesses and conditions.
Stem cells are drawn to inflammation because of a unique, inherent characteristic. Regeneration of damaged or diseased tissues, reduction of inflammation and modulation of the immune system have been demonstrated to improve health and quality of life.
If you’ve been diagnosed with post-acute COVID-19 syndrome, you may anticipate less long-term problems, faster healing, less chronic COVID-19 symptoms, and less inflammation all throughout your body going forward.